High‐Throughput Methods to Detect Long Non‐Coding RNAs
نویسندگان
چکیده
منابع مشابه
Long Noncoding RNAs
Ma Recent studies suggest that the majority of the human genome is transcribed, but only about 2% accounts for proteincoding exons. Long noncoding RNAs (lncRNAs) constitute a heterogenic class of RNAs that includes, for example, intergenic lncRNAs, antisense transcripts, and enhancer RNAs. Moreover, alternative splicing can lead to the formation of circular RNAs. In support of putative function...
متن کاملHigh-Throughput Methods to Detect Long Non-Coding RNAs
Increasing evidence suggests that the numbers of long non-coding RNAs (lncRNAs) are more than those of protein-coding genes in various organisms. Although the detection methods for lncRNAs are being increasingly established, there are advantages and disadvantages that exist for each method. In this opinion article, I highlight the differences between microarrays and RNA sequencing (RNA-seq) for...
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Mouse embryonic fibroblasts isolated from females lacking Xist intron 1 display normal Xist RNA coating. Image courtesy of K. Plath. Where Do Phenotypes eXIST? Xist encodes a lncRNA that is responsible for mediating X chromosome inactivation (XCI) to achieve dosage compensation in mammalian females. Previous work has indicated that binding of pluripotency factors, such as Oct4, Sox2, and Nanog,...
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Aging is associated with increasing the risk of disease and death. Recently, increasing evidences suggest that many long noncoding RNAs (lncRNAs) function through specific interactions with other cellular factors, namely proteins, DNA, and other RNA molecules. LncRNAs play important roles in a wide range of age-related diseases, such as cancer, cardiovascular pathologies, and neurodegenerative ...
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The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not been explored. Here we profiled the transcript...
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ژورنال
عنوان ژورنال: High-Throughput
سال: 2017
ISSN: 2571-5135
DOI: 10.3390/ht6030012